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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes High Fever While Having Antibiotics For TB?

my son, 15 years old, 90% likely TB ( Xray chest shows infection, Blood TB Gold test positive, arm test - 48 hrs observation shows radish area) . He got upto 105 F fever with shiverling cold withinn 30 mins of durataion of starting of fever. mostly in night Doctor has started TB medicine rifampicin 150mg, isoniazid 75mg, pyraziamide 400mg, ethambutol hydrocholoride 275 mg ( 3 tablets at a time after 1 hr h of dinner ) the other supportive medicine like antibitotics (amoxy + ?) and electrolytes are there along with PCM injustion ( on required base). Please suggest why so high fever?
Tue, 3 Feb 2015
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General & Family Physician,  's  Response
Hi there

How long ago has your son started the TB medication? Was the fever there before starting medication? TB itself does cause fever which commonly occurs every 12hours or so. If he has just started the medication I would give it some time (4 weeks) before the fever will settle down. In the mean time the use of antipyretics such as Paracetamol 500mg QID will help. The fever may also be due to the response generated by the Anti-TB treatment from killing the TB organism.

However , we should also take into consideration the effect of TB drugs on the body. There are many side effects from TB medication. One of the most common side effects is the effect on liver enzymes. Look out for Jaundice. He should have a liver function test done(LFT) and follow up from there.
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What Causes High Fever While Having Antibiotics For TB?

Hi there How long ago has your son started the TB medication? Was the fever there before starting medication? TB itself does cause fever which commonly occurs every 12hours or so. If he has just started the medication I would give it some time (4 weeks) before the fever will settle down. In the mean time the use of antipyretics such as Paracetamol 500mg QID will help. The fever may also be due to the response generated by the Anti-TB treatment from killing the TB organism. However , we should also take into consideration the effect of TB drugs on the body. There are many side effects from TB medication. One of the most common side effects is the effect on liver enzymes. Look out for Jaundice. He should have a liver function test done(LFT) and follow up from there.