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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes High Uric Acid And Creatinine Levels?

My husband has been having high uric acid levels and has bilateral uric acid stones. He does not have gout. His creatinine levels increased in a week. He is in stage 3 Kidney disease. We haven t received any answers to what is going on. Do you have any information?
Mon, 4 May 2015
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Radiologist,  's  Response
Hi,
Thanks for writing in.

Uric acid and creatinine are excretory products which are regularly filtered out of our system by the kidneys. If your husband is having grade 3 kidney disease it means that the ability of the kidneys to remove creatinine and uric acid from the blood is reduced. This is causing above normal uric acid and creatinine in the circulation and is seen when his blood sample is evaluated for these metabolic products.

Gout is a different condition where there is primary hyperuricemia and deposition of uric acid crystals in joints. Uric acid is a product of purine metabolism which is a type of protein. When there is abnormality in purine metabolism then there is high levels of uric acid in blood and it forms crystals which affect joints. Please do not worry.
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What Causes High Uric Acid And Creatinine Levels?

Hi, Thanks for writing in. Uric acid and creatinine are excretory products which are regularly filtered out of our system by the kidneys. If your husband is having grade 3 kidney disease it means that the ability of the kidneys to remove creatinine and uric acid from the blood is reduced. This is causing above normal uric acid and creatinine in the circulation and is seen when his blood sample is evaluated for these metabolic products. Gout is a different condition where there is primary hyperuricemia and deposition of uric acid crystals in joints. Uric acid is a product of purine metabolism which is a type of protein. When there is abnormality in purine metabolism then there is high levels of uric acid in blood and it forms crystals which affect joints. Please do not worry.