What Causes Muscle Spasms In The Thumb?

can a ganglion cyst ( or other bump sort of thing because I m not sure if its a cyst or something worse) cause uncontrollable muscle twitching it has been on my hand for a long while now, I read somewhere its best not to mess with them and let them heal or dissolve on there own, but I m quite concerned with recent muscle spasm my thumb twitches randomly now and I noticed its almost as it goes with my heart beat, could it be blood passing threw my body and puts pressure on the cyst and makes the muscles react? and is there any way to remove a cyst quite large or small without surgery, I have heard hit it with a book to pop it, but I dont want to pop it incase its filled with a toxic fluid much regard too you please and thank you