Hello, Thanks for your query. After going through the description, I understand your concern regarding your symptoms.There are numerous causes for Muscle spasms. Some of the common causes are - Dehydration - Muscle fatigue - Poor blood circulation in the legs - Deficiency of either Calcium or Vitamin - Diabetes - Neurological problems like a pinched nerve in the lower back - Hypokalemia (low serum potassium levels) - Drug induced like, chronic use of STATINS, DIURETICS, ANTIASHTMATICS etc Activities that might help prevent muscle spasms include: • Drinking plenty of fluids to avoid dehydration • Stretching your thigh muscles or riding a stationary bicycle for a few minutes • Massaging the cramped muscle with your hands or with ice • Walking or jiggling the leg I do hope that you have found something helpful and I will be glad to answer any further query. Take care