hello thank you for trusting HCM dear Seeing unabsorbed medications in your stool does not necessarily mean that there is anything wrong with your colon or digestion. Pharmaceutical companies make many different types of medication coatings from extended release coatings to cellulose capsules. In most cases, the body is absorbing the medications as it should and expelling the shell of the medication. The outer coating or capsule of certain medications have a very specific purpose. Long-acting or extended-release medications have a special coating that is designed to slowly absorb. It s similar to the digestion of corn kernels — your body digests the inner grain of corn, but the tough, fibrous husk is expelled. The liquids and waste from your body refill the corn husk — and likewise some medication husks — making them appear full and unabsorbed. if you are taking medications for diabetes and your blood sugar remains within a normal range, there is a good chance the medications are getting absorbed properly. If the medications are moving through your system too fast or not being absorbed appropriately, there is a chance that you will see the whole tablet or capsule in the toilet. few causes are Gastrointestinal viruses,Food Intolerances,Lactose intolerance,Irritable Bowel Syndrome Irritable Bowel Disease,Celiac Disease,Crohn s Disease,.HIV/AIDS. read the drug pamphlet Cannot be taken at the same time. Should be administered on an empty (or full) stomach.Should not be taken with specific supplements, such as vitamins.Can not be taken with certain juices, such as grapefruit juice. please consult your doctor he will examine and treat you accordingly. take care