hello thank you for trusting HCM Dear Alpha anti-chymotrypsin is a protein produced primarily during the acute phases of inflammation. It serves to prevent excess tissue damage that can result from proteolytic enzymes that are released by mast cells and neutrophils during the acute inflammatory response. Stool alpha anti-chymotrypsin levels increase at times of GI inflammation, particularly of the small intestine. High stool levels of this protein are typically associated with inflammatory bowel diseases, especially Crohn’s disease (likely due to its tendency to affect the small intestine), but it can also be elevated in acute intestinal inflammation secondary to other causes. I think I answered to your question if you have more questions feel free to ask. take care