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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Is The Cure For Grand Mal Seizures With A History Of HSV And Partial Hysterectomy?

I have had at least 3 grand mal seizures in the past month and started Keppra after the first seizure and had a dosage increase after the 2nd seizure. No prior hx of seizure for me or my family,. I drink an alcoholic beverage about 2 to 4 times a year . I do have a hx of HSV 2 and partial hysterectomy. I am 46.
Tue, 8 Jul 2014
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Psychiatrist,  's  Response
HI THANKS FOR POSTING YOUR QUERY.LET ME FIRST TELL YOU THAT THERE IS VERY CLOSE ASSOCIATION BETWEEN HERPES SIMPLEX VIRUS HSV2 AND GRAND MAL EPILEPSY.HSV IF INFECTS THE BRAIN CAN CAUSE HEMORRAGHIC ENCEPHALITIS OF TEMPORAL LOBE WHICH CAN BE FORERUNNER OF A SEIZURE/CONVULSIVE ACTIVITY.SUCH SEIZURES ARE WUITE RESISTANT TO ANTI EPILEPTIC MEDICATIONS.ALCOHOLIC DRINKS ARE WELL KNOWN TO INCREASE THE SEIZURE ACTIVITY UNPREDICTABLY.I SUGGEST YOU GRADUALLY REDUCE THE CONSUMPTION OF ALCOHOL.IT ADVICE YOU TO GET AN MRI BRAIN-FAST SPIN ECHO BASED TO RULE OUT ANY ORGANIC LESION AS IT EARLIER MENTIONED THAT POSSIBLE WITH HERPES.
CURRENTLY YOU ARE PLACED ON KEPPRA WHICH IS AN ADD ON DRUG FOR GRAND MAL SEIZURES.YOU NEED TO HAVE A BASELINE/FIRST CHOICE DRUG CALLED VALPROATE SEMISODIUM TO TREAT THE SEIZURE ACTIVITY.THE BEST POSSIBLE DOSE TO CONTROL THE SEIZURE ACTIVITY IS CHOSEN.SERUM DRUG MONITORING CAN BE HELPFUL.ONLY ADD ON DRUGS MIGHT NOT BE EFFECTIVE IN YOUR CASE AS IS EVIDENT FROM RECURRENT SEIZURE ACTIVITY.INCASE IF YOUR CSF TESTING/MRI REVEALED THE PRESENCE OF HSV,THEN ANTIVIRAL THERAPY WITH ACYCLOVIR HAS TO BE INITIATED PROMPTLY.
YOUR BLOOD PRESSURE SEEMS TO BE IN NORMAL LEVELS,BUT CONTINUE RECORDING YOUR BLOOD PRESSURE AT FREQUENT INTERVLS.CONSULT AN EXPERT NEUROPHYSICIAN TO TACKLE YOUR ROBLEM.
THANK YOU
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What Is The Cure For Grand Mal Seizures With A History Of HSV And Partial Hysterectomy?

HI THANKS FOR POSTING YOUR QUERY.LET ME FIRST TELL YOU THAT THERE IS VERY CLOSE ASSOCIATION BETWEEN HERPES SIMPLEX VIRUS HSV2 AND GRAND MAL EPILEPSY.HSV IF INFECTS THE BRAIN CAN CAUSE HEMORRAGHIC ENCEPHALITIS OF TEMPORAL LOBE WHICH CAN BE FORERUNNER OF A SEIZURE/CONVULSIVE ACTIVITY.SUCH SEIZURES ARE WUITE RESISTANT TO ANTI EPILEPTIC MEDICATIONS.ALCOHOLIC DRINKS ARE WELL KNOWN TO INCREASE THE SEIZURE ACTIVITY UNPREDICTABLY.I SUGGEST YOU GRADUALLY REDUCE THE CONSUMPTION OF ALCOHOL.IT ADVICE YOU TO GET AN MRI BRAIN-FAST SPIN ECHO BASED TO RULE OUT ANY ORGANIC LESION AS IT EARLIER MENTIONED THAT POSSIBLE WITH HERPES. CURRENTLY YOU ARE PLACED ON KEPPRA WHICH IS AN ADD ON DRUG FOR GRAND MAL SEIZURES.YOU NEED TO HAVE A BASELINE/FIRST CHOICE DRUG CALLED VALPROATE SEMISODIUM TO TREAT THE SEIZURE ACTIVITY.THE BEST POSSIBLE DOSE TO CONTROL THE SEIZURE ACTIVITY IS CHOSEN.SERUM DRUG MONITORING CAN BE HELPFUL.ONLY ADD ON DRUGS MIGHT NOT BE EFFECTIVE IN YOUR CASE AS IS EVIDENT FROM RECURRENT SEIZURE ACTIVITY.INCASE IF YOUR CSF TESTING/MRI REVEALED THE PRESENCE OF HSV,THEN ANTIVIRAL THERAPY WITH ACYCLOVIR HAS TO BE INITIATED PROMPTLY. YOUR BLOOD PRESSURE SEEMS TO BE IN NORMAL LEVELS,BUT CONTINUE RECORDING YOUR BLOOD PRESSURE AT FREQUENT INTERVLS.CONSULT AN EXPERT NEUROPHYSICIAN TO TACKLE YOUR ROBLEM. THANK YOU