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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Why Are The Titer Going Up In Positive ANA Tested 8 Year Old?

Hi my 8 year old daughter had a positive ANA test of tiger 1:80 about a week and a half ago no symptoms but two of her toe nails changed color they look a little black I got her retested last Thursday still positive with a 1:160 titer DNA and RNP are both negative what can be wrong why are the titer going up
Mon, 11 Dec 2017
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Pediatrician, Pulmonology 's  Response
Hi.... raising titres of ANA are suggestive of active disease process in a case of connective tissue disorder or autoimmunity. This may be suggestive of systemic onset or pauciarticular or polyarticular juvenile rheumatoid arthritis. I suggest you consult your pediatrician regarding this.

As you said ds DNA is negative SLE is an unlikely possibility.

Regards - Dr. Sumanth
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Why Are The Titer Going Up In Positive ANA Tested 8 Year Old?

Hi.... raising titres of ANA are suggestive of active disease process in a case of connective tissue disorder or autoimmunity. This may be suggestive of systemic onset or pauciarticular or polyarticular juvenile rheumatoid arthritis. I suggest you consult your pediatrician regarding this. As you said ds DNA is negative SLE is an unlikely possibility. Regards - Dr. Sumanth