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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Will It Be Safe To Take Valporic Acid ,Dexadrin And Ambilify For Seizures?

Hello, I have a 25 year old Special Needs daughter that has ben having Grand Mall Seizures for the last three years. she was seizure free for almost 2 years while on 100mg of Lamotrigin however in July of 2013 (no triggers)she started them again and her Lamotrogin has been increased to the maximum 400 mg per day over three weeks ago. She had two GMS on May 18 and now her Dr.wants to add Valporic Acid to her daily meds. She is also on Dexadrin, Ambilify and Cymbalta. My question is , is all off these meds. safe for her to take at the same time? And is there some kind of surgery that is available for people with GMS?
posted on Sun, 25 May 2014
Twitter Tue, 12 Jun 2018 Answered on
Twitter Wed, 13 Jun 2018 Last reviewed on
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Neurologist,  's  Response
Hello and Welcome to ‘Ask A Doctor’ service.
I have reviewed your query and here is my advice.

Without knowing more details about your daughter and where/who is evaluating her and making decisions to add/increase meds it is difficult to give you a definite answer. However, so long as someone with knowledge and expertise is taking care of her taking the meds you describe can be safely done though it is a fair amount to be sure. Still her seizures need to be controlled. There is a surgery for Refractory seizures that can be done but this should only be considered after it is clear that no reasonable option exists. For example, there is something called a VAGAL STIMULATOR that can be highly successful. Has that been considered. There are a number of other newer medications on the market for Generalized Tonic Clonic seizures (we don't really say GMS any more), have all possible sources of infection been looked for as cause to her sudden increase? Has her metabolism somehow changed? Hope I have answered your query. Let me know if I can assist you further.
Regards,
Dr. Dariush Saghafi
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Will It Be Safe To Take Valporic Acid ,Dexadrin And Ambilify For Seizures?

Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. Without knowing more details about your daughter and where/who is evaluating her and making decisions to add/increase meds it is difficult to give you a definite answer. However, so long as someone with knowledge and expertise is taking care of her taking the meds you describe can be safely done though it is a fair amount to be sure. Still her seizures need to be controlled. There is a surgery for Refractory seizures that can be done but this should only be considered after it is clear that no reasonable option exists. For example, there is something called a VAGAL STIMULATOR that can be highly successful. Has that been considered. There are a number of other newer medications on the market for Generalized Tonic Clonic seizures (we don t really say GMS any more), have all possible sources of infection been looked for as cause to her sudden increase? Has her metabolism somehow changed? Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Dariush Saghafi