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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Will Liver Functions Return To Normal After Stopping Losartan?

I am 53 I am 5'6' and weigh 158 I was started on Norvasc 5mg and losartan 100mg in April. Had previously been on lisinopril and spirolatone, anyway when labs checked in September I had elevated liver fucntion tests, I asked the doctor then if it could be result of switching to the new medicine as I had not had elevated liver tests when on the other medicine. I was switched off the other due to how it was making me feel. I was left on the norvasc and losartan and at the same doses. The doctor had me return Nov 8 to check liver function tests and they had gone up I belive the alk phos was at 240, and alt or ast had went for 54 to 68. A hepatitis panel was done and was negative. I had ultrasounds done on liver, pancreas, bile duct and gall bladder and these were perfectly normal. I have no abdominal pain, no nausea, no vomiting, no loose stools no abnormal stools, no fever. I again asked the doctor if medicine could be cause as I had looked on internet and found that norvasc has caused hepatitis severe enough to lead to hospitalization. When I told him this he then looked it up on his pda and found that i was correct and that losartan also could affect the liver so these were both stopped. I have refused to take anything until I go back to get liver rechecked the 12th of dec. My blood pressures have been ok. Today it was 128/88. My concern is will by liver be permanently affected and will liver functions return to normal





Tue, 5 Apr 2016
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General & Family Physician 's  Response
Hi thanks for asking question...
Noted you was taking antihypertensive medication...
Yes you could have drug induce hepatitis.
It is reversible condition..

Rest your liver with low fat diet.
Regular exercise.
Avoid alcohol...

And you are hypertensive patient.
If blood pressure normal then maintainance low dose can be taken ...
But don't self stoppage of drug done without doctor consultation...
Close follow up done....
With low dose antihypertensive drug now your enzymes level gradually within normal limit...

Take care.

Dr.Parth Goswami
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Will Liver Functions Return To Normal After Stopping Losartan?

Hi thanks for asking question... Noted you was taking antihypertensive medication... Yes you could have drug induce hepatitis. It is reversible condition.. Rest your liver with low fat diet. Regular exercise. Avoid alcohol... And you are hypertensive patient. If blood pressure normal then maintainance low dose can be taken ... But don t self stoppage of drug done without doctor consultation... Close follow up done.... With low dose antihypertensive drug now your enzymes level gradually within normal limit... Take care. Dr.Parth Goswami