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What Causes Elevated WBC And WBC Esterase In Urine?

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Posted on Thu, 3 Jul 2014
Question: I continually have WBC and WBC esterase in urine w/o bacteria. Cystoscopy did not reveal IC I do have chronic cystitis and thickened bladder wall. I was on Cypro for 2 months and do not want to go back on it again. Any suggestions as to what is going on?
doctor
Answered by Dr. Manuel C See IV (1 hour later)
Brief Answer:
Tests are needed to determine etiology.

Detailed Answer:
Good Day and thank you for being with Healthcare Magic!

WBC is the presence of pus cells in the urine (pyuria) and can be found most commonly in the presence of urinary tract infection (UTI) but can also found in numerous inflammatory conditions. Examples of these would be urethral syndrome, tuberculosis of the urinary tract, diabetes, interstitial nephritis and interstitial cystitis.

First and foremost I would recommend a urine culture for typical and atypical bacteria. Urine culture is the gold standard in the detection of urinary tract infection and usually catches 90% of the infection. Polymerase chain reaction (PCR) is also a valuable accurate test to rule out chlamydia and other organisms that will not grow on culture. If the organism is detected then the appropriate treatment will be started to eradicate the infection.

Once infection has been ruled out then other causes of pyuria will be entertained. Do you have voiding complaints? urinary frequency? urinary urgency? weak urinarystream? I am concerned about your chronic cystitis and thickened bladder wall which may be due to obstruction. Due to your advanced age I am likely to think that you may have atrophic urethritis due to menopause. Atrophic urethritis leads to chronic obstruction the bladder causing thickening of the bladder and will definitely have inflammatory cells or pus cells in the urine.

Treatment for atrophic urethritis would start with vaginal estrogen suppositories and estrogen creams to the urethra to regain the normal lining of the urethra. If there is no improvement after a few months then an outpatient procedure can be done to dilate/open the urethra to relieve the obstruction.

I hope I have succeeded in providing the information you were looking for. Please feel free to write back to me for any further clarifications at: http://www.HealthcareMagic.com/doctors/dr-manuel-c-see-iv/66014 I would gladly help you. Best wishes.

Regards,

Manuel C. See IV, M.D. DPBU FPUA

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Manuel C See IV (46 hours later)
Hello, I just received my urine culture results. It read Organism     Citrobacter freundii          
10,000-100,000 CFU/ml. Is this easy to clear up with antibiotic? Is it common? In the past my cultures were all neg. I am quite concerned since I was on Cipro from January to March. I just finished 4 days again last Thursday. I will see an Urologist tomorrow. I would appreciate your input. Thank you in advance.
doctor
Answered by Dr. Manuel C See IV (12 hours later)
Brief Answer:
It is a uropathogen and can be treated with abx.

Detailed Answer:
Good Day and thank you for being with Healthcare Magic!

yes citrobacter is not uncommon pathogen of the urinary system and can be treated with the usual antibiotics. the sensitivity results will tell us which antibiotic would be appropriate for the bacteria. most probably the bacteria is already resistant to ciprofloxacin and your Urologist will prescribe a different antibiotic that is based on the culture.

I hope I have succeeded in providing the information you were looking for. Please feel free to write back to me for any further clarifications at: http://www.HealthcareMagic.com/doctors/dr-manuel-c-see-iv/66014 I would gladly help you. Best wishes.
Note: Consult a Urologist online for consultation about prostate and bladder problems, sexual dysfunction, kidney stones, prostate enlargement, urinary incontinence, impotence and erectile dysfunction - Click here.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Manuel C See IV

Urologist

Practicing since :2005

Answered : 909 Questions

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What Causes Elevated WBC And WBC Esterase In Urine?

Brief Answer: Tests are needed to determine etiology. Detailed Answer: Good Day and thank you for being with Healthcare Magic! WBC is the presence of pus cells in the urine (pyuria) and can be found most commonly in the presence of urinary tract infection (UTI) but can also found in numerous inflammatory conditions. Examples of these would be urethral syndrome, tuberculosis of the urinary tract, diabetes, interstitial nephritis and interstitial cystitis. First and foremost I would recommend a urine culture for typical and atypical bacteria. Urine culture is the gold standard in the detection of urinary tract infection and usually catches 90% of the infection. Polymerase chain reaction (PCR) is also a valuable accurate test to rule out chlamydia and other organisms that will not grow on culture. If the organism is detected then the appropriate treatment will be started to eradicate the infection. Once infection has been ruled out then other causes of pyuria will be entertained. Do you have voiding complaints? urinary frequency? urinary urgency? weak urinarystream? I am concerned about your chronic cystitis and thickened bladder wall which may be due to obstruction. Due to your advanced age I am likely to think that you may have atrophic urethritis due to menopause. Atrophic urethritis leads to chronic obstruction the bladder causing thickening of the bladder and will definitely have inflammatory cells or pus cells in the urine. Treatment for atrophic urethritis would start with vaginal estrogen suppositories and estrogen creams to the urethra to regain the normal lining of the urethra. If there is no improvement after a few months then an outpatient procedure can be done to dilate/open the urethra to relieve the obstruction. I hope I have succeeded in providing the information you were looking for. Please feel free to write back to me for any further clarifications at: http://www.HealthcareMagic.com/doctors/dr-manuel-c-see-iv/66014 I would gladly help you. Best wishes. Regards, Manuel C. See IV, M.D. DPBU FPUA