HI, thanks for using healthcare magic Though medications can be associated with side effects, it is quite possible that his symptoms are related to withdrawal of nicotine since he recently stopped smoking. Some of the symptoms that can occur with smoking cessation are: anxiety, difficulty concentrating, depression, insomnia, restlessness. These symptoms eventually resolve. The use of nicotine replacements may help. These can come in various forms such as patches, sprays, gum,inhalors. There are also medications that can be used for persons trying to stop smoking to help the process. Ramipril is not normally associated with changes in mood. He may want to consult a psychologist or psychiatrist if his symptoms continue. I hope this helps