Thanks for your question Nick. To answer the first part of your question The outlook for people diagnosed with Paget s disease is generally good, particularly if treatment is given before major changes have occurred in the affected bones. Life expectancy is not altered and the chances of developing osteogenic sarcoma is less than 1 %. Also note that disease does not spread to normal bones To answer your second question Bone pain can require anti-inflammatory drugs (NSAIDs) or pain-relieving medicines. Prior to undergoing surgery on bone affected by Paget s disease, it is helpful for doctors to treat patients with medications, such as bisphosphonates or calcitonin (Miacalcin), as this tends to diminish the risk of surgical complications, including bleeding Bisphosphonates are the mainstay of treatment for Paget s disease of bone Let me tell you Nick that I cannot inform the dosage over the Internet as tests have to be run specially your Liver profile to decide the dosage. Therefore I suggest you talk to your treating physician about the dosage of bisphosphonates and calcitonin I can however suggest Ibuprofen 800mg twice a day for your pain I hope this helped. Take care