Hello dear, Though there are no strict restrictions to be followed while taking rabies vaccination, it is advisable to stay away from alcohol & smoking because of the following reasons: 1. There may be unexplained interactions between efficacy of the vaccine and alcohol intake/smoking. 2. Rabies vaccination provides immunity against rabies infection while consumption of alcohol & smoking decreases the body immunity. This is scientifically proven in various studies. 3. Individuals who receive the Rabies vaccine may experience symptoms such as headache, nausea, dizziness, etc. which are similiar to the symptoms experienced by intake of alcohol. Based on the above mentioned facts, it is better to avoid smoking & alcohol consumption. Other than that, you also need to avoid hepato toxic drugs & steroids. Wishing you a good health. Take care.