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Dr. Andrew Rynne
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Article Home Adult and Senior Health Factor XIII Deficiency

Factor XIII Deficiency

It is a very rare disorder causing severe bleeding. Factor X111 or fibrin stabilizing factor is an enzyme of the blood coagulation system.


It is rare autosomal recessive disease which is associated with severe bleeding episodes. It is also been seen in association with hepatic failure, inflammatory bowel disease and myeloid leukemia. It can be acquired or congenital.


Factor X111 deficiency


Signs and symptoms

  • Persistent bleeding from the umbilical stump of the umbilical cord.
  • Soft tissue and subcutaneous bleeding
  • Menorrhagia
  • CNS hemorrhage
  • Hemarthroses
  • Recurrent spontaneous abortions in women
  • Delayed wound healing


  • Blood work up including activated partial thromboplastin time
  • Immunological assays
  • Coagulation screening tests
  • Assessment of clot stability
  • Genotyping


Plasma, cryoprecipitates and factor X111 concentrates are used for replacement