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Dr. Andrew Rynne
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Article Home Children's Health Idiopathic Neonatal Hepatitis

Idiopathic Neonatal Hepatitis

Idiopathic Neonatal Hepatitis is rare life-threatening condition where for unknown reason iron accumulates in the liver of the fetus and produces severe symptoms after birth, during the fetal or infant stage death is common.


Neonatal hepatitis is a common term used for inflammation of the liver (hepatitis) that is seen to occur shortly after birth in newborns may be caused by viruses, certain metabolic disorders, and other rare diseases that affect or impair the function of the liver. In some children, the cause of liver inflammation is unknown -these cases are called Idiopathic neonatal hepatitis (INH). The symptoms of idiopathic neonatal hepatitis may vary greatly from one individual to another. 

Idiopathic Neonatal Hepatitis

Signs and symptoms

  • Bile duct obstruction
  • Jaundice
  • Pale stool
  • Dark urine
  • Enlarged liver
  • Slowed growth
  • Irritability
  • Itching
  • Hepatomegaly


  • Death
  • Stillbirth
  • Death due to liver failure


There is no specific treatment for this disease supportive and symptomatic treatment is given.

Depending on the severity of the jaundice phlebotomy - exchange blood transfusion is done as per the need.

Symptomatic treatment according to the serum transaminase and serum ferritn level is carried on.

Approximately 80 percent of individuals with idiopathic neonatal hepatitis fully recover from the condition.