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Dr. Andrew Rynne
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Article Home Adult and Senior Health Quincke Syndrome

Quincke Syndrome

Quincke's edema or familial angioneurotic edema is an rare variant of urticaria, associated or not, that involves the subcutaneous cell tissue and mucous of the upper air digestive tract and face.



  • Quincke's edema involves swelling of deep skin layers and fatty tissues under the skin as well as the mucous membrane.
  • The condition involves recurrent swelling of tissues, abdominal pain and swelling of the voice box.
  • It is often caused by an allergic reaction to drugs or food. It is also called giant urticaria, angioedema, Quincke’s edema or angioneurotic edema.


Quincke’s syndrome


Causative factors

  • Food related products for Quincke's edema associated with urticaria.
  • Drugs like penicillin, aspirin, phenytoin and others,
  • Infection- bacterial and viral
  • Venoms, medication and food can induce anaphylaxis in sensitized individuals.


Hereditary angio-oedema is an autosomal-dominant disorder associated with recurrent episodes of edema of the subcutaneous tissue without.


Onset is usually in early childhood but may be delayed even into late adult life.


Serum levels of C1-esterase inhibitor are either extremely low, or the inhibitor is apparently non-functional.


Symptoms and signs of Quienke’s syndrome

  • Skin swelling
  • Mucous membrane swelling
  • Abdominal pain
  • Purpura
  • Fever
  • Voice box swelling
  • Joint pain  


Complications and sequelae of quinke’s syndrome


  • Abdominal pain
  • Pruritus
  • Urticaria



Angioneurotic odema is a medical emergency, it always better to seek the medical help immediately


  • To give airway support in case of medical support
  • Anti histamines
  • Corticosteroids
  • Adrenaline in acute condition
  • C1 esterase inhibitors in case of hereditary angioneurotic edema