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Dr. Andrew Rynne
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Article Home Children's Health Giant Cell Disease of the Liver

Giant Cell Disease of the Liver

It is the liver injury in new borns inwhom the infectious and metabolic disease have been excluded. It is also called as idiopathic neonatal hepatitis. It is charecterized by presence of mulitnucleated gaint cells.

Giant Cell Disease of the Liver

It is also known as congenital liver cirrhosis, giant cell hepatitis, neonatal hepatitis..

This disease occurs in early infancy manifested by jaundice in the second to eight week of life and the course is variable resolving completely in 40 percent of the patients.
In some ther ewill be fibrosisl leading to diffuse portal cirrhosis.The disease is rare.


  • Hemogram.
  • Bonemarrow examaintion.
  • Icterus index.
  • Serum bilirubin.
  • Vanden bergh reaction positive.
  • Liver fucntion tests.
  • Liver biopsy showed numerous syncytial gaint cells with granular sytoplasm and chronic inflammatory cells in the portal tract.

It is closely realted to following disease

  • Acute Viral Hepatitis a
  • Alcoholic Steatonecrosis
  • Chronic Aggressive Hepatitis
  • Chronic Lobular Hepatitis
  • Congenital Liver Cirrhosis
  • Delta Agent
  • Diffuse Hepatocellular Inflammatory Disease
  • Giant Cell Disease of the Liver
  • Giant Cell Hepatitis
  • Hbv
  • Hepatitis Delta Virus
  • Idiopathic Neonatal Hepatitis
  • Infectious Hepatitis
  • Ischemic Hepatitis
  • Lupoid Hepatitis
  • Mild Chronic Hepatitis
  • Persistent Hepatitis
  • Sclerosing Hyaline Necrosis
  • Serum Hepatitis
  • Shock Liver
  • Toxic Hepatitis
  • Viral Hepatitis